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Institut für Virologie
am Department für Hygiene,
Mikrobiologie und Publich Health
der Medizinischen Universität Innsbruck

Peter-Mayr-Straße 4b
A-6020 Innsbruck

Tel.: 0512/9003-71701
Fax: 0512/9003-73701
E-Mail: virologie@i-med.ac.at

About | Projects | Team |Publications |Calender-News | Links

PUBLICATIONS (oncolytic virus group D von Laer)

1. Dold C, Urbiola CR, Wollmann G, Egerer L, Muik A, Bellmann L, Fiegl H, Marth C, Kimpel J & von Laer D. 2016. Application of Interferon Modulators to Overcome Partial Resistance of Human Ovarian Cancers to VSV-GP Oncolytic Viral Therapy. Mol Ther Oncolytics, ACCEPTED.


2. Muik, A., Stubbert, LJ., Jahedi, RZ., Geiß, Y., Kimpel, J., Dold, C., Tober, R., Volk, A., Klein, S., Dietrich, U., Yadollahi, B., Falls, T., Miletic, H., Stojdl, D., Bell, JC., von Laer, D.: Re-engineering vesicular stomatitis virus to abrogate neurotoxicity, circumvent humoral immunity, and enhance oncolytic potency. Cancer Research 2014 Jul 1;74(13):3567-78.


3. Muik, A., Dol, C., Geiß, Y., Volk, A., Werbizki, M., Dietrich, U., von Laer, D.: Semireplication-competent vesicular stomatitis virus as a novel platform for oncolytic virotherapy. J Mol Med (Berl). 2012 Aug;90(8):959-70.


4.  Muik, A., Kneiske, I., Werbizki, M., Wilflingseder, D., Giroglou, T., Ebert, O., Kraft, A., Dietrich, U., Zimmer, G., Momma, S., von Laer, D.: Pseudotyping vesicular stomatitis virus with lymphocytic choriomeningitis virus glycoproteins enhances infectivity for glioma cells and minimizes neurotropism. J Virol. Jun;85(11):5679-8, 2011.


5. Huszthy, P.C., Goroglou, T., Tsinkalovsky, O., Euskirchen, P., Skaftnesmo, K.O., Bjerkvig, R., *von Laer, D., *Miletic, H.: Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapy. PlosONE 4(7):e6314, (Jul 20) 2009. *contributed equally


6. Miletic, H., Fischer, Y., Giroglou, T., Rueger, M.A., Li, H., Himmelreich, U., Stenzel, W., Jacobs, A.H., von Laer, D.: Normal brain cells contribute to the bystander effect in a suicide gene therapy - approach for malignant glioma using lentiviral pseudotyped vectors. Clin. Cancer Res. 13:6761-8, 2007.


7.  Miletic, H., Fischer, Y., Litwak, S., Giroglou, T., Waerzeggers, Y., Winkeler, S., Rueger, A., Himmelreich, U., Stenzel, W., Deckert, M., Jacobs, A.H., Neumann, H., von Laer, D.: Bystander-mediated killing of malignant glioma by bone marrow derived adult progenitor cells expressing a suicide gene. Mol. Ther. 15:1373-81, 2007.


8.  Miletic, H., Fischer, Y., Neumann, H., Hans, V., Giroglou, T., Deckert, M., von Laer, D.: Selective transduction of malignant glioma by lentiviral vectors pseudotyped with LCMV glycoproteins. Hum. Gene Ther. 15:1091-1100, 2004.


9. Beyer, W., Westphal, M., Ostertag, W., von Laer, D.: Oncoretroviral and lentiviral vectors pseudotyped with lymphocytic choriomeningitis virus glycoprotein: generation, concentration and broad host range. J. Virol. 76:1488-1495, 2002.


1.Dold C, Urbiola CR,
Wollmann G, Egerer L, Muik A, Bellmann L, Fiegl H, Marth C, Kimpel J & von Laer D. 2016. Application of Interferon Modulators to Overcome Partial Resistance of Human Ovarian Cancers to VSV-GP Oncolytic Viral Therapy. Mol Ther Oncolytics, ACCEPTED.

2.Wollmann G, Drokhlyansky E, Davis JN, Cepko C, van den Pol AN. 2015. Lassa-vesicular stomatitis chimeric virus safely destroys brain tumors. J Virol. 89:6711-24.

3.Wollmann G, Paglino JC, Maloney PR, Ahmadi SA, van den Pol AN. 2015. Attenuation of vesicular stomatitis virus infection of brain using antiviral drugs and an adeno-associated virus-interferon vector. Virology. 475:1-14.

4.Wollmann G, Davis JN, Bosenberg MW, van den Pol AN. 2013. Vesicular stomatitis virus variants selectively infect and kill human melanomas but not normal melanocytes. J Virology. 87:6644-59.

5.Wollmann G, Ozduman K, van den Pol AN. 2012. Oncolytic virus therapy for glioblastoma multiforme: concepts and candidates. Cancer J. 18:69-81.

6.Wollmann G, Rogulin V, Simon I, Rose JK, van den Pol AN. 2010. Some attenuated variants of vesicular stomatitis virus show enhanced oncolytic activity against human glioblastoma cells relative to normal brain cells. J Virology. 84:1563-1573.

7.Ozduman K, Wollmann G, Ahmadi SA, van den Pol AN. 2009. Peripheral immunization blocks lethal actions of vesicular stomatitis virus within the brain. J  Virology. 83:11540-11549.

8.van den Pol AN, Ozduman K, Wollmann G, Ho WS, Simon I, Yao Y, Rose JK, Ghosh P. 2009.  Viral strategies for studying the brain, including a replication-restricted self-amplifying delta-G vesicular stomatis virus that rapidly expresses transgenes in brain and can generate a multicolor golgi-like expression. J Comp Neurol. 516:456-481.

9.Ozduman K, Wollmann G, Piepmeier JM, van den Pol AN. 2008. Systemic vesicular stomatitis virus selectively destroys multifocal glioma and metastatic carcinoma in brain. J Neurosci. 28:1882-1893.

10.Baehring JM, Phipps M, Wollmann G. 2008. Rostral midbrain infarction producing isolated lateropulsion. Neurology. 70:655-656.

11.Wollmann G, Robek MD, van den Pol AN. 2007. Variable deficiencies in the interferon response enhance susceptibility to VSV oncolytic actions in glioblastoma but not in normal human glia. J. Virology. 81:1479-1491.

12.van den Pol AN, Robek MD, Ghosh PK, Ozduman K, Bandi P, Whim MD, Wollmann G. 2007. Cytomegalovirus induces interferon-stimulated gene expression and is attenuated by interferon in the developing brain. J. Virology. 81:332-348.

13.Wollmann G, Lenzner S, Berger W, Rosenthal R, Karl MO, Strauß O. 2006. Voltage-dependent ion channels in the mouse RPE: comparison with Norrie disease mice. Vision Res. 46:688-698.

14.Wollmann, G, Acuna-Goycolea C, van den Pol AN. 2005. Direct excitation of hypocretin/orexin cells by extracellular ATP at P2X receptors. J Neurophysiol. 94:2195-2206.

15.Wollmann G, Tattersall P, van den Pol AN. 2005. Targeting human glioblastoma cells: comparison of nine viruses with oncolytic potential. J. Virology. 79: 6005-6022.

16.Ortego J, Wollmann G, Coca-Prados M. 2002. Differential regulation of gene expression of neurotensin and prohormone convertases PC1 and PC2 in the bovine ocular ciliary epithelium: possible implications on neurotensin processing. Neurosci Lett. 333:49-53.

17.Strauss O, Rosenthal R, Dey D, Beninde J, Wollmann G, Thieme H, Wiederholt M. 2002. Effects of protein kinase C on delayed rectifier K+ channel regulation by tyrosine kinase in rat retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 43:1645-1654.

18.Bertazolli-Filho R, Ghosh S, Huang W, Wollmann G
, Coca-Prados M. 2001. Molecular evidence that human ocular ciliary epithelium expresses components involved in phototransduction. Biochem Biophys Res Commun. 284:317-325.